L-DAB HBR
L-DAB HBR Basic information
- Product Name:
- L-DAB HBR
- Synonyms:
-
- L-2,4-DIAMINOBUTYRIC ACID HYDROBROMIDE
- L-DAB HBR
- L-DAB HYDROBROMIDE
- L-2,4-Diaminobutanoate
- H-DabHBr
- (S)-2,4-Diaminobutyric acid
- L-DABA
- (S)-2,4-diaminobutanoic acid
- CAS:
- 1758-80-1
- MF:
- C4H10N2O2
- MW:
- 118.13
- Product Categories:
-
- Unusual Amino Acids
- Amino hydrochloride
- Mol File:
- 1758-80-1.mol
L-DAB HBR Chemical Properties
- Melting point:
- 216-218 °C
- Boiling point:
- 321.0±32.0 °C(Predicted)
- Density
- 1.218±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- form
- Powder
- pka
- 2.00±0.10(Predicted)
- color
- White to off-white
- CAS DataBase Reference
- 1758-80-1(CAS DataBase Reference)
L-DAB HBR Usage And Synthesis
Uses
L-DABA (L-2,4-Diaminobutyric acid) is a week GABA transaminase inhibitor with an IC50 of larger than 500 μM; exhibits antitumor activity in vivo and in vitro.
Definition
ChEBI: A 2,4-diaminobutyric acid that has S-configuration.
in vivo
Treatment with L-DABA results in 43.4% reduction of tumor growth[1]. L-DABA is a more effective inhibitor of GABA transaminase in vivo than in vitro[2].
IC 50
Human Endogenous Metabolite
References
[1] Ronquist G, et al. Antitumor activity of L-2,4 diaminobuturic acid against mouse fibrosarcoma cells in vitro and in vivo. J Cancer Res Clin Oncol. 1980;96(3):259-68. DOI:10.1007/BF00408098
[2] Beart PM, et al. l-2,4-Diaminobutyric acid and the GABA system. Neurosci Lett. 1977 Jul;5(3-4):193-8. DOI:10.1016/0304-3940(77)90046-5
[3] Panasci L, et al. The cytolytic effect of L-2,4 diaminobutyric acid with malignant glioma cells and fibroblasts. Cancer Chemother Pharmacol. 1988;21(2):143-4. DOI:10.1007/BF00257361
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L-DAB HBR(1758-80-1)Related Product Information
- 2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL ISOCYANATE
- 2,4-Dichlorophenyl isocyanate
- FMOC-DAP(MTT)-OH
- FMOC-D-DAP(ALOC)-OH
- FMOC-D-DAP(DDE)-OH
- Fmoc-Dap(Alloc)-OH
- FMOC-D-DAP(IVDDE)-OH
- N-α –Fmoc-N-β-1-(4,4-dimethyl-2,6-dioxocyclohe
- FMOC-D-DAP(BOC)-OH
- DL-2,4-DIAMINOBUTYRIC ACID DIHYDROCHLORIDE
- FMOC-DOPA(ACETONIDE)-OH
- FMOC-D-DAP(MTT)-OH
- Fmoc-D-Dap(Ac)-OH
- (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-acetamidopropanoic acid
- N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE
- 2,4-DIAMINO-BUTYRIC ACID
- L-DAB HBR
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