ICA-105574 Chemical Properties

Boiling point:

430.9±30.0 °C(Predicted)

Density 

1.333±0.06 g/cm3(Predicted)

storage temp. 

room temp

solubility 

DMSO: >20mg/mL

pka

11.76±0.70(Predicted)

color 

off-white to light tan

InChI

InChI=1S/C19H14N2O4/c22-19(14-5-4-6-16(13-14)21(23)24)20-15-9-11-18(12-10-15)25-17-7-2-1-3-8-17/h1-13H,(H,20,22)

InChIKey

GDWKBKTVROCPNZ-UHFFFAOYSA-N

SMILES

C(NC1=CC=C(OC2=CC=CC=C2)C=C1)(=O)C1=CC=CC([N+]([O-])=O)=C1

Safety Information

Hazard Codes 

Xi,N

Risk Statements 

36-43-50/53

Safety Statements 

26-36/37-60-61

RIDADR 

UN 3077 9 / PGIII

ICA-105574 Usage And Synthesis

Description

ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC50 value of 0.5 +/- 0.1 μM and a Hill slope (n(H)) of 3.3 +/- 0.2. ICA-105574 shifts the voltage dependence of Ptype inactivation to a very positive direction and removes the hERG channel from inactivation at physiological membrane potentials[1].

References

[1] Mahoko Asayama . “Effects of an hERG Activator, ICA-105574, on Electrophysiological Properties of Canine Hearts.” Journal of pharmacological sciences 121 1 (2013): Pages 1-8.