3,3',5-TRIIODOTHYROACETIC ACID Chemical Properties

Melting point:

65°; mp 180-183°

Boiling point:

531.6±50.0 °C(Predicted)

Density 

2.466±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated)

form 

Solid

pka

4.02±0.10(Predicted)

color 

White to Pale Beige

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22

Safety Statements 

36

WGK Germany 

3

HS Code 

2916.39.7900

MSDS

• Language:English Provider:SigmaAldrich

3,3',5-TRIIODOTHYROACETIC ACID Usage And Synthesis

Chemical Properties

White to Off-White Solid

Originator

Triacana,Ana,Italy,1972

Uses

thyroid agent

Uses

3,3'',5-Triiodo Thyroacetic Acid (T3-Acetic Acid (USP)) is a thyroid hormone analogue. A potent Thyroxine impurity. Levothyroxine EP Impurity C.

Manufacturing Process

Preparation of 3:5-diiodo-4-(4'-hydroxyphenoxy)phenylacetic acid (diacid): A solution of ethyl 3:5-diiodo-4-(4'-methoxyphenoxy)phenyl acetate (9.5 g) in acetic acid (60 ml) was heated under reflux with hydroiodic acid (SG 1.7, 50 ml) and red phosphorus (0.5 g) for 1 hour. The hot solution was filtered and the filtrate concentrated at 50°C and 15 mm of mercury to above 20 ml. The residue was treated with water (70 ml) containing a little sodium thiosulfate to decolorize the product. The solid was collected by filtration and purified by the method of Harington and Pitt-Rivers [Biochem. J. (1952), Vol. 50, page 438]. Yield 8.36 g (95%). After crystallization from 70% (v/v) acetic acid it melted at 219°C.
A solution of 438 mg of diac in methanol (20 ml) and ammonia solution (SG 0.88; 20 ml) was iodinated at 0°C with 1.8 ml 1 N iodine solution. The product was isolated in almost theoretical yield in a manner similar to that described for tetrac. After crystallization from 50% (v/v) methanol, triac was obtained as colorless needles which melted over the range 65°C to 90°C according to the rate of heating. The molten form resolidified at about 110°C and finally melted at 180°C to 181°C without decomposition. The compound, dried at 25°C/3 mm over silica gel, contains methanol of crystallization.

Therapeutic Function

Thyroid hormone

3,3',5-TRIIODOTHYROACETIC ACID(51-24-1)Related Product Information

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