1-BOC-3,5-DIMETHYL-PIPERAZINE Chemical Properties

Melting point:

70-71°

Boiling point:

279.7±15.0℃ (760 Torr)

Density 

0.970±0.06 g/cm3 (20 ºC 760 Torr)

Flash point:

123.0±20.4℃

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

pka

8.58±0.60(Predicted)

form 

solid

Appearance

White to off-white Solid

InChI

InChI=1/C11H22N2O2/c1-8-6-13(7-9(2)12-8)10(14)15-11(3,4)5/h8-9,12H,6-7H2,1-5H3/t8-,9+

InChIKey

NUZXPHIQZUYMOR-DTORHVGONA-N

SMILES

N1(C(OC(C)(C)C)=O)C[C@H](C)N[C@H](C)C1 |&1:9,12,r|

Safety Information

Hazard Codes 

N

Risk Statements 

36/37/38-50

Safety Statements 

26-61

RIDADR 

UN3077

1-BOC-3,5-DIMETHYL-PIPERAZINE Usage And Synthesis

Uses

1-Boc-cis-3,5-dimethyl-piperazine is used in the identification of 7-(3-(Piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent, selective and orally bioavailable PI3Kδ inhibitors.

Description

1-BOC-3,5- dimethylpiperazine is a heterocyclic derivative and can be used as pharmaceutical intermediates.

Uses

1-Boc-cis-3,5-dimethyl-piperazine is used in the identification of 7-(3-(Piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent, selective and orally bioavailable PI3Kδ inhibitors.

Description

SOCS3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 262 amino acids (1-225 a.a) and having a molecular mass of 29kDa.SOCS3 is fused to a 37 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli

Background

Suppressor of Cytokine Signaling 3, also known as SOCS3 belongs to the SOCS family; in addition SOCS3 is a member of the STAT-induced STAT inhibitor (SSI). The SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of SOCS3 is induced by different cytokines, including IL6 and IL10. SOCS3 can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of SOCS3 have shown the roles of SOCS3 in the negative regulation of fetal liver hematopoiesis, and placental development.

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