NIPRADILOL Chemical Properties

Melting point:

110-122℃

Boiling point:

464.39°C (rough estimate)

Density 

1.1829 (rough estimate)

refractive index 

1.6280 (estimate)

Safety Information

Toxicity

LD50 i.v. in mice, rats: 74.0, 73.0 mg/kg; orally in mice: 540 mg/kg (Shiratsuchi, 1988)

NIPRADILOL Usage And Synthesis

Description

Nipradilol is a beta-blocker with vasodilatory activity. As an antihypertensive nipradilol decreases systemic/pulmonary arterial blood pressure, heart rate, cardiac output and left ventricular volume without causing tachycardia. Nipradilol is also reported to have antiangina activity in dogs.

Originator

Kowa (Japan)

Uses

Nipradolol is a β-adrenoceptor blocking agent with antihypertensive properties.?Nipradolol is used as an?anti-glaucomatous agent.

Definition

ChEBI: Hypadil (TN) is an organic molecular entity.

brand name

Hypadil

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