gamma-Benzyl L-glutamate Chemical Properties

Melting point:

181-182 °C(lit.)

alpha 

27.2 º (c=2, 1N HCL)

Boiling point:

379.78°C (rough estimate)

Density 

1.2026 (rough estimate)

refractive index 

1.5200 (estimate)

storage temp. 

2-8°C

solubility 

Acetic Acid (Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Heated)

pka

2.20±0.10(Predicted)

form 

Powder

color 

White

optical activity

[α]20/D +19±2°, c = 1% in acetic acid

BRN 

1885646

CAS DataBase Reference

1676-73-9(CAS DataBase Reference)

EPA Substance Registry System

L-Glutamic acid, 5-(phenylmethyl) ester (1676-73-9)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

TSCA 

Yes

HazardClass 

IRRITANT

HS Code 

29224999

MSDS

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gamma-Benzyl L-glutamate Usage And Synthesis

Chemical Properties

white powder

Uses

L-Glutamic acid γ-benzyl ester is commonly used in the synthesis of polymers for biological applications. Some of the examples are:

• Synthesis of bioreducible block copolymers based on poly(ethylene glycol) and poly(γ-benzyl L-glutamate) for Intracellular drug delivery.
• Synthesis of biodegradable poly(L-glutamic acid)-b-polylactide for magnetic resonance imaging (MRI)-visible drug delivery system.
• Synthesis of pH and temperature-responsive diblock copolymers based on poly(L-glutamic acid).

Purification Methods

Recrystallise the ester from H2O and store it at 0o. [Estrin Biochemical Preparations 13 25 1971, Beilstein 6 IV 2538.]

gamma-Benzyl L-glutamate(1676-73-9)Related Product Information

• L-Glutamic acid dibenzyl ester 4-toluenesulfonate
• Benzyl acetate
• Benzyl chloroformate
• Benzyl formate
• Benzyl alcohol
• Benzyl butyrate
• Benzyl chloride
• H-GLU(OBZL)-OBZL HCL
• L-Glutamic acid
• Benzyl benzoate
• Benzyl nicotinate
• Benzyl propionate
• Benzyl carbamate
• H-GLU(OALL)-OALL P-TOSYLATE
• synthesis-021-HCl
• L-Glutamic acid 5-cyclohexyl ester
• H-Gln(Trt)-OH.H2O
• Diethyl L-glutamate hydrochloride