Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  API >  Respiratory Drugs >  Asthma drugs >  Seratrodast

Seratrodast

Basic information Safety Supplier Related

Seratrodast Basic information

Product Name:
Seratrodast
Synonyms:
  • 50MG/200MG/1G
  • benzeneheptanoic acid, -(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)-
  • (+-)-7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoicacid
  • aa-2414
  • beta-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)-bezeneheptanoicaci
  • Seratrodast(AA-2414,ABT-001)
  • AA-2414;SERETRA;AA2414;AA 2414
  • Seretra
CAS:
112665-43-7
MF:
C22H26O4
MW:
354.44
EINECS:
692-169-8
Product Categories:
  • ZAGAM
  • API
  • Heterocyclic Compounds
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
112665-43-7.mol
More
Less

Seratrodast Chemical Properties

Melting point:
118-120°C
Boiling point:
522.3±49.0 °C(Predicted)
Density 
1.140±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
pka
4.76±0.10(Predicted)
form 
Yellow-orange solid.
Merck 
14,8459
CAS DataBase Reference
112665-43-7(CAS DataBase Reference)
More
Less

Safety Information

RTECS 
DA1600050
More
Less

Seratrodast Usage And Synthesis

Description

Seratrodast, a novel benzoquinone derivative, is the first thromboxane A2 (TxA2) receptor antagonist to reach the market. It is orally active for the treatment of bronchospastic disorders such as asthma. TxA2, a metabolite of the arachidonate cascade, is involved in several cardiovascular and respiratory diseases through its potent biological effects on platelet aggregation and constriction of vascular and respiratory smooth muscles. Seratrodast potently inhibits platelet aggregation and bronchoconstriction induced by a TxA2 mimic and by a variety of spasmogenic prostanoids including PGF, PGD2 and 9α,11β-PGF2. Seratrodast shows excellent efficacy in asthma and has been reported to be potentially useful in hyper-responsive disorder. The R-(+)- seratrodast was reported to be the active isomer.

Chemical Properties

Pale Orange Solid

Originator

Takeda (Japan)

Uses

Thromboxane A2-receptor antagonist. Antiasthmatic.

Uses

antibacterial

Uses

Thromboxane A2-receptor antagonist. Antiasthmatic

brand name

Bronica

Biological Activity

Thromboxane A 2 (TP) receptor antagonist. Antiasthmatic agent; inhibits platelet aggregation and bronchoconstriction induced by a TXA 2 mimetic in guinea pigs.

Seratrodast Preparation Products And Raw materials

Raw materials

SeratrodastSupplier

Shandong Lukang Pharmaceutical Co., Ltd. Gold
Tel
0537-2983357
Email
lukanggongsi@lkpc.com
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Email
jkinfo@jkchemical.com;market6@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Email
3bsc@sina.com
Chembest Research Laboratories Limited
Tel
021-20908456-
Email
sales@BioChemBest.com
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Email
Sales-CN@TCIchemicals.com