2-Chloromethoxyethylchloride Chemical Properties

Boiling point:

147 °C

Density 

1,28 g/cm³

refractive index 

1.4570-1.4600

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

Chloroform

form 

Oil

color 

Yellow

Safety Information

Risk Statements 

10-23/24/25-34

Safety Statements 

16-26-36-45

RIDADR 

2929

HS Code 

2909.19.1800

HazardClass 

6.1/3

PackingGroup 

II

2-Chloromethoxyethylchloride Usage And Synthesis

Chemical Properties

Yellow Oil. 2-Chloromethoxyethylchloride is soluble in most commonly used organic solvents, including ethereal (THF, diethyl ether), halogenated (CH2Cl2, CHCl3, CCl4), and hydrocarbon solvents; incompatible with alcohol solvents.

Uses

(2-Chloroethoxy)methyl Chloride (cas# 1462-33-5) is a compound useful in organic synthesis.

Synthesis

The most conveniently prepared of 2-Chloromethoxyethylchloride is by reaction of 2-chloroethanol and 1,3,5-trioxane with HCl(g) at 0 °C (1.0 mol scale, 66% yield).

Precautions

2-Chloromethoxyethylchloride is a deviate of Chloromethyl ethers, which are recognized carcinogens. The reagent should be prepared and handled in an efficient fume hood, and skin contact should be avoided. Chloromethyl ethers are also moisture-sensitive and should be stored and transferred under an inert atmosphere. Excess reagent should be hydrolyzed in water before removing it from the fume hood.

References

1. Ogle, C. A.; Wilson, T. E.; Stowe, J. A. S 1990, 495.
2. Hutchison, A. J.; Kishi, Y. JACS 1979, 101, 6786.
3. Farren, J. W.; Fife, H. F.; Clark, F. E.; Garland, C. E. JACS 1925, 47, 2419.
4. For similar procedures, see ref 5 and Holy, A.; Rosenberg, I.; Dvorakova, H. CCC 1989, 54, 2190 (4.6 mol scale, 74% yield)

2-Chloromethoxyethylchloride(1462-33-5)Related Product Information

• Poly(tetrahydrofuran)
• Chloromethyl isopropyl carbonate
• 2-Butoxyethanol
• (2-Methoxyethyl)benzene
• tert-Butyl methyl ether
• Dimethyl disulfide
• Dimethyl ether
• Ethylbenzene
• 2-Methoxyethyl chloride
• Diethyl ether
• Chloromethyl methyl ether
• 2-Chloroethyl chloroformate
• 2,2,2-Trichloroethyl chloroformate
• (+/-)-1,2,2,2-TETRACHLOROETHYL CHLOROFORMATE
• 2,2,2-TRICHLORO-1,1-DIMETHYLETHYL CHLOROFORMATE
• KS 504a
• 1,2,3-Trichloropropane-2,3-oxide
• 2-Chloromethoxyethylchloride