AMYLOID BETA-PROTEIN (1-40) (MOUSE, RAT) Chemical Properties

storage temp. 

-15°C

solubility 

Soluble to 1 mg/ml in 1% Ammonia

form 

Solid

color 

White to off-white

Sequence

H-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH

AMYLOID BETA-PROTEIN (1-40) (MOUSE, RAT) Usage And Synthesis

Uses

β-Amyloid (1-40) (rat) is a rat form of the amyloid β-peptide, which accumulates as an insoluble extracellular deposit around neurons, giving rise to the senile plaques associated with Alzheimer's disease (AD). β-Amyloid (1-40) (rat) increases 45Ca2+ influx, induces neurodegeneration in the rat hippocampal neurons of the CA1 subfield. β-Amyloid (1-40) (rat) induces apoptosis. β-Amyloid (1-40) (rat) can be used for the research of Alzheimer's disease[1][2].

in vivo

storage

Desiccate at -20°C

References

[1] MacManus A, et, al. Enhancement of (45)Ca(2+) influx and voltage-dependent Ca(2+) channel activity by beta-amyloid-(1-40) in rat cortical synaptosomes and cultured cortical neurons. Modulation by the proinflammatory cytokine interleukin-1beta. J Biol Chem. 2000 Feb 18;275(7):4713-8. DOI:10.1074/jbc.275.7.4713
[2] Miguel-Hidalgo JJ, et, al. Beta-amyloid(1-40)-induced neurodegeneration in the rat hippocampal neurons of the CA1 subfield. Acta Neuropathol. 1998 May;95(5):455-65. DOI:10.1007/s004010050825
[3] Prediger RD, et, al. Differential susceptibility following beta-amyloid peptide-(1-40) administration in C57BL/6 and Swiss albino mice: Evidence for a dissociation between cognitive deficits and the glutathione system response. Behav Brain Res. 2007 Feb 27;177(2):205-13. DOI:10.1016/j.bbr.2006.11.032

AMYLOID BETA-PROTEIN (1-40) (MOUSE, RAT)(144409-98-3)Related Product Information

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