2,2-Difluoro-1,3-benzodioxole Chemical Properties

Boiling point:

129-130°C

Density 

1,308 g/cm³

refractive index 

1.443

Flash point:

129-130°C

storage temp. 

2-8°C

solubility 

Chloroform, Methanol

form 

Oil

color 

Clear Colourless

BRN 

1307648

InChIKey

DGCOGZQDAXUUBY-UHFFFAOYSA-N

LogP

2.96

CAS DataBase Reference

1583-59-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-43

Safety Statements 

26-36/37/39-36/37

RIDADR 

UN1993

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

3

PackingGroup 

III

HS Code 

2932990090

MSDS

• Language:English Provider:ALFA

2,2-Difluoro-1,3-benzodioxole Usage And Synthesis

Uses

2,2-Difluoro-1,3-benzodioxole is an intermediate compound which is used especially for the preparation of products for agricultural chemistry and for the synthesis of pharmaceutical products.
2,2-difluoro-1,3-benzodioxole is a useful difluoromethylated building block for the synthesis of various benzodioxole-containing pharmaceutical active compounds.
2-,3-,and 4-(Trifluoromethoxy)phenyllithiums: Versatile intermediates offering access to a variety of new organofluorine compounds.
Selective aliphatic fluorination by halogen exchange in mild conditions.

Preparation

2,2-Difluoro-1,3-benzodioxole is prepared by reaction of 2,2-dichloro-1,3-benzodioxole with potassium fluoride in the presence of an effective quantity of a catalyst selected from potassium hydrogen fluoride, sodium hydrogen fluoride, cesium hydrogen fluoride, rubidium hydrogen fluoride, and quaternary ammonium hydrogen fluoride.
https://patents.google.com/patent/US5432290A/en

References

[1] E.Castagnetti, et al, Eur. J. Org. Chem., 2001, 2001(4), pp 691-695.
[2] L.Saint-Jalmes, J. F. Chem., 2006, 127(1), pp 85-90.

Chemical Properties

Colorless to pale yellow liquid

Uses

2,2-Difluoro-1,3-benzodioxole is used in the synthesis of Kv3 inhibitors as well as in the preparation of renin inhibitors.

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