OKADAIC ACID SODIUM SALT Chemical Properties

storage temp. 

-20°C

solubility 

Soluble in DMSO or ethanol

form 

film

color 

translucent

biological source

plant (Prorocentrum concavum)

Water Solubility 

water: 1mg/mL
DMSO: 20mg/mL
ethanol: 20mg/mL

Safety Information

Hazard Codes 

T

Risk Statements 

23/24/25-38

Safety Statements 

26-36/37-45

RIDADR 

UN 3462 6.1/PG 1

WGK Germany 

3

HazardClass 

6.1

HS Code 

29321900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

OKADAIC ACID SODIUM SALT Usage And Synthesis

Chemical Properties

white to off-white solid

Uses

Potent inhibitor of serine/threonine-specific protein phosphatases 1 and 2A (PP1 and PP2A). Does not inhibit tyrosine or alkaline phosphatases

Biochem/physiol Actions

Dinoflagellate toxin and an ionophore-like polyether derivative of a 38 carbon, fatty acid. Readily enters cells. Inhibitor of type 1 and type 2A protein phosphatases. Does not inhibit tyrosine phosphatases, alkaline phosphatases or acid phosphatase. Known tumor promotor. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling.

in vivo

IC 50

PP1: 15-50 nM (IC₅₀); PP2A: 0.1-0.3 nM (IC₅₀); PP3: 3.7-4 nM (IC₅₀); PP4: 0.1 nM (IC₅₀); PP5: 3.5 nM (IC₅₀); PP2B: ~4000 nM (IC₅₀); PP7: >1000 nM (IC₅₀)

storage

Store at -20°C (desiccate)

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