1-(1-(3-methoxyphenyl)-7-propoxyindolizin-3-yl)ethanone Chemical Properties

Density 

1.12±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO: 25 mg/mL (77.31 mM)

form 

Solid

color 

Light yellow to yellow

1-(1-(3-methoxyphenyl)-7-propoxyindolizin-3-yl)ethanone Usage And Synthesis

Uses

GSK8573 is an inactive control compound for GSK2801 (acetyl-lysine competitive inhibitor of BAZ2A and BAZ2B bromodomains). GSK8573 has binding activity to BRD9 with a Kd value of 1.04 μM and is inactive against BAZ2A/B and other bromodomain familiy. GSK8573 can be used as a structurally related negative control compound in biological experiments[1].

IC 50

BRD9: 1.04 μM (Kd)

References

[1] Chen P, et al. Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B. J Med Chem. 2016 Feb 25;59(4):1410-24. DOI:10.1021/acs.jmedchem.5b00209

1-(1-(3-methoxyphenyl)-7-propoxyindolizin-3-yl)ethanone(1693766-04-9)Related Product Information

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