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5,7-Dichloro-8-hydroxyquinoline

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5,7-Dichloro-8-hydroxyquinoline Basic information

Product Name:
5,7-Dichloro-8-hydroxyquinoline
Synonyms:
  • 5,7-Dichlor-8-hydroxychinolin
  • 5,7-Dichloro-8-hydroquinoline
  • 5,7-Dichloro-8-hydroxyquinolin
  • 5,7-Dichloro-8-oxychinolin
  • 5,7-Dichloro-8-oxyquinoline
  • 5,7-dichloro-8-quinolino
  • 5,7-Dichlorooxine
  • 5,7-Dichloroxine
CAS:
773-76-2
MF:
C9H5Cl2NO
MW:
214.05
EINECS:
212-258-3
Product Categories:
  • CINAZYN
  • Building Blocks
  • C8 to C10
  • Chemical Synthesis
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Quinolines, Quinazolines and derivatives
  • Haloquinolines
  • Hydroxyquinolines
  • Quinolines
Mol File:
773-76-2.mol
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5,7-Dichloro-8-hydroxyquinoline Chemical Properties

Melting point:
178-180 °C (lit.)
Boiling point:
305.47°C (rough estimate)
Density 
1.3320 (rough estimate)
refractive index 
1.5500 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly, Heated, Sonicated)
pka
2.30±0.30(Predicted)
form 
Fluffy Powder
color 
Light beige
Merck 
14,2175
BRN 
153606
Stability:
Light Sensitive
CAS DataBase Reference
773-76-2(CAS DataBase Reference)
NIST Chemistry Reference
8-Quinolinol, 5,7-dichloro-(773-76-2)
EPA Substance Registry System
8-Quinolinol, 5,7-dichloro- (773-76-2)
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Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
22-37/38-41-36/37/38
Safety Statements 
26-36-37/39-25-22
WGK Germany 
3
RTECS 
VC5350000
TSCA 
Yes
HS Code 
29334900

MSDS

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5,7-Dichloro-8-hydroxyquinoline Usage And Synthesis

Chemical Properties

light beige fluffy powder

Uses

H1 antihistamine

Uses

Analytical reagent.

Uses

Chloroxine, is an impurity of Cioquinol, which is an antifungal and antiprotozoal drug.

Indications

Chloroxine (Capitrol) shampoo contains a synthetic antibacterial compound similar to the hydroxyquinoline compounds used in dermatology for many years.

Definition

ChEBI: Quinolin-8-ol in which the hydrogens at positions 5 and 7 have been substituted by chlorine. An synthetic antibacterial prepared by chlorination of quinolin-8-ol, it is used for the treatment of dandruff and seborrhoeic dermatitis of the scalp.

brand name

Capitrol (Westwood- Squibb).

Purification Methods

Crystallise the dichloro-oxine from acetone/EtOH. [Beilstein 21 H 95.]

5,7-Dichloro-8-hydroxyquinoline Preparation Products And Raw materials

Raw materials

5,7-Dichloro-8-hydroxyquinolineSupplier

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