Propargyl-PEG4-acid Chemical Properties

Boiling point:

388.0±37.0 °C(Predicted)

Density 

1.129±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Soluble in Water, DMSO, DCM, DMF

pka

4.28±0.10(Predicted)

Propargyl-PEG4-acid Usage And Synthesis

Description

Propargyl-PEG4-acid is a PEG reagent with an alkyne and a terminal carboxylic acid. The carboxylic acid reacts with primary amine groups with the help of activators (e.g. EDC, or HATU). The 4-unit PEG spacer increases hydrophilicity. The alkyne can participate in copper-catalyzed Click Chemistry.

Uses

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^? molecules) for targeted protein degradation.

Propargyl-PEG4-acid(1415800-32-6)Related Product Information

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• Propargyl-PEG5-t-butyl ester
• Propargyl-PEG3-t-butyl ester
• Propargyl-PEG4-methylamine