(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine hydrochloride Chemical Properties

storage temp. 

Sealed in dry,Room Temperature

Appearance

White to light yellow Solid

(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine hydrochloride Usage And Synthesis

Synthesis

General procedure for the synthesis of (3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-dien-7-yl)methanamine hydrochloride from 4,5-dimethoxy-1-cyanobenzocyclobutane: reference to EP 0 534 859 Step 1: Preparation of 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-amine hydrochloride. To a solution of 25 g of 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile dissolved in 250 ml of tetrahydrofuran (THF) at room temperature was added slowly and dropwise 312 ml of borane-THF complex solution with continuous stirring for 12 hours. Subsequently, 200 mL of ethanol was added and stirring was continued for 1 hour. 100 ml of a 3.3 N solution of ethyl ether hydrochloride was added slowly and dropwise. Eventually 27.7 g of the target product was obtained in 90% yield with a melting point of 205°C.

References

[1] Patent: US2014/107334, 2014, A1. Location in patent: Paragraph 0052-0055
[2] Patent: US2014/128598, 2014, A1. Location in patent: Paragraph 0044-0047
[3] Patent: US2014/163220, 2014, A1. Location in patent: Paragraph 0040-0043

(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine hydrochloride(35202-55-2)Related Product Information

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