Mal-PEG2-t-butyl ester Chemical Properties

Boiling point:

465.1±35.0 °C(Predicted)

Density 

1.161±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

Liquid

pka

-2.34±0.20(Predicted)

color 

Colorless to light yellow

Mal-PEG2-t-butyl ester Usage And Synthesis

Description

Mal-PEG3-t-butyl ester is a PEG linker containing a maleimide group and a t-butyl ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Uses

Mal-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Mal-PEG2-t-butyl ester(518044-35-4)Related Product Information

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