Propargyl-PEG6-amine Chemical Properties

Boiling point:

401.8±40.0 °C(Predicted)

Density 

1.058±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. -20°C

solubility 

Soluble in Water, DMSO, DCM, DMF

pka

8.74±0.10(Predicted)

form 

Liquid

color 

Colorless to light yellow

Propargyl-PEG6-amine Usage And Synthesis

Description

Propargyl-PEG6-amine is a crosslinker with a hydrophilic PEG spacer which can increase the hydrophilicity of the molecule in aqueous environment. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry.

Uses

Propargyl-PEG6-NH2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Propargyl-PEG6-NH2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

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