t-Boc-N-amido-PEG8-acid
t-Boc-N-amido-PEG8-acid Basic information
- Product Name:
- t-Boc-N-amido-PEG8-acid
- Synonyms:
-
- 5,8,11,14,17,20,23,26-Octaoxa-2-azanonacosanedioic acid, 1-(1,1-dimethylethyl) ester
- t-Boc-N-amido-PEG8-acid
- t-Boc-N-amido-PEG9-acid
- Boc-N-amido-PEG8-acid
- T-BOC-NH-AMIDO-PEG8-COOH
- t-Boc-N-amido-PEG8-COOH,Boc-N-amido-PEG8-acid
- Boc-NH-PEG8-acid
- 2,2-Dimethyl-4-oxo-3,8,11,14,17,20,23,26,29-nonaoxa-5-azadotriacontan-32-oic acid
- CAS:
- 1334169-93-5
- MF:
- C24H47NO12
- MW:
- 541.63
- Product Categories:
-
- peg
- Mol File:
- 1334169-93-5.mol
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t-Boc-N-amido-PEG8-acid Chemical Properties
- Boiling point:
- 627.6±55.0 °C(Predicted)
- Density
- 1.122±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C, sealed storage, away from moisture
- solubility
- Soluble in Water, DMSO, DCM, DMF
- pka
- 4.28±0.10(Predicted)
- form
- Liquid
- color
- Colorless to light yellow
- InChI
- InChI=1S/C24H47NO12/c1-24(2,3)37-23(28)25-5-7-30-9-11-32-13-15-34-17-19-36-21-20-35-18-16-33-14-12-31-10-8-29-6-4-22(26)27/h4-21H2,1-3H3,(H,25,28)(H,26,27)
- InChIKey
- XYVCCDSFTREKQJ-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O
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t-Boc-N-amido-PEG8-acid Usage And Synthesis
Description
t-Boc-N-amido-PEG8-acid is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Uses
Boc-NH-PEG8-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
t-Boc-N-amido-PEG8-acidSupplier
Shaanxi Xinyan Bomei Biotechnology Co., Ltd. Gold
- Tel
- 13892832556
- 2440688701@qq.com
Shanghai Yanfen Biochemical Technology Co.,LTD Gold
- Tel
- 17721070236 15002190549;
- yanfen2023@126.com
CHENGDU YINGNUOLING PHARMACEUTICAL TECHNOLOGY CO.,LTD Gold
- Tel
- 17882285575
- 1276966012@qq.com
Alabiochem Tech.Co., Ltd.
- Tel
- 512-58900862 400-0707518
- sales@alabiochem.com
ChemPep, Inc.
- Tel
- +1 (888) 615-9178 / (561) 791-8787
- service@chempep.com
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t-Boc-N-amido-PEG8-acid(1334169-93-5)Related Product Information
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