5,6-DICHLORO-2-METHYLBENZIMIDAZOLE Chemical Properties

Melting point:

238-240

Boiling point:

409.0±25.0 °C(Predicted)

Density 

1.486

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

powder to crystal

pka

9.94±0.10(Predicted)

color 

White to Orange to Green

CAS DataBase Reference

6478-79-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Hazard Note 

Irritant

HS Code 

2933998090

5,6-DICHLORO-2-METHYLBENZIMIDAZOLE Usage And Synthesis

Uses

5,6-Dichloro-2-methylbenzimidazole is a benzimidazole with antiparasitic activity. It also shows aminopyrine demethylase-inhibiting activity.

Synthesis

GENERAL METHOD: A mixture of 4,5-dichloro-1,2-phenylenediamine (200 mg, 1.85 mmol) and ethyl acetoacetate (722 mg, 5.55 mmol) was added with GdCl3-6H2O (25 mg, 0.09 mmol), and the reaction mixture was stirred for 3.0 hours at 80 °C. After completion of the reaction (monitored by TLC), the reaction mixture was poured into ice-cold water and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 5,6-dichloro-2-methylbenzimidazole crude. The crude product was further purified by column chromatography with the eluent being a hexane solution of 10% ethyl acetate.

References

[1] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2015, vol. 54B, # 8, p. 953 - 957

5,6-DICHLORO-2-METHYLBENZIMIDAZOLE(6478-79-1)Related Product Information

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