Loxoprofen Chemical Properties

Melting point:

108.5-111°

Boiling point:

bp0.3 190-195°

Density 

1.182±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

solid

pka

4.39±0.10(Predicted)

color 

White to Off-White

Merck 

14,5589

InChI

InChI=1S/C15H18O3/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16/h5-8,10,13H,2-4,9H2,1H3,(H,17,18)

InChIKey

YMBXTVYHTMGZDW-UHFFFAOYSA-N

SMILES

C(C1CCCC1=O)C1C=CC(C(C)C(=O)O)=CC=1

CAS DataBase Reference

68767-14-6(CAS DataBase Reference)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

HS Code 

2918.99.3000

Storage Class

11 - Combustible Solids

MSDS

• Language:English Provider:2-{4-[(2-Oxocyclopentyl)methyl]phenyl}propanoic acid
• Language:English Provider:SigmaAldrich

Loxoprofen Usage And Synthesis

Uses

antiinflammatory, analgesic

Uses

Loxoprofen is a non-selective nonsteroidal anti-inflammatory drug (NSAID) that has been effective in reducing atherosclerosis in mice by reducing inflammation. Loxoprofen becomes active after metabolism in the body and inhibits the activation of cyclooxygenase.

Definition

ChEBI: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-[(2-oxocyclopentyl)methyl]phenyl group. A prodrug that is rapidly converted to its active trans-alcohol metabolite following ora administration.

Synthesis

Ethyl 2-oxocyclopentanecarboxylate and potassium hydroxide in dimethylformamide were reacted with ethyl 2-(4-chloro-phenyl)propionate at 80 ??C for 2 h. The product obtained was reacted with 47% hydrobromic acid and hydrolyzed and decarboxylated to give loxoprofen.

Loxoprofen(68767-14-6)Related Product Information

• Chlorodimethylphenylsilane
• Kresoxim-methyl
• Methyl salicylate
• Methylcyclopentane
• Methanol
• Methylparaben
• Tribenuron methyl
• Tri(o-tolyl)phosphine
• Propionic acid
• Methyl acrylate
• PHENYL VALERATE
• 2,2-Bis(hydroxymethyl)propionic acid
• Basic Violet 1
• Cyclopentane
• Silicone oil (high temperature)
• Loxoprofen Related Compound 5
• Loxoprofen Related Compound 13
• 2-[(4-Acetylphenyl)methyl]cyclopentan-1-one