MI-136
MI-136 Basic information
- Product Name:
- MI-136
- Synonyms:
-
- MI-136
- MI-136;HY-19319 (MI 136; MI136);
- HY-19319 (MI 136
- 1H-Indole-2-carbonitrile, 5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-
- MI136;MI 136
- CS-2162
- 5-[[4-[[6-(2,2,2-Trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1H-indole-2-carbonitrile
- 5-((4-((6-(2,2,2-Trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-in
- CAS:
- 1628316-74-4
- MF:
- C23H21F3N6S
- MW:
- 470.51
- Mol File:
- 1628316-74-4.mol
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MI-136 Chemical Properties
- Boiling point:
- 654.9±55.0 °C(Predicted)
- Density
- 1.45±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: 10 mg/ml
- form
- A crystalline solid
- pka
- 14.20±0.30(Predicted)
- color
- White to off-white
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MI-136 Usage And Synthesis
Description
MI-136 is an inhibitor of the menin-MLL interaction (IC50 = 31 nM; Kd = 23.6 nM). By blocking MLL recruitment predominantly at the level of the menin-MLL interaction, it can inhibit androgen receptor (AR)-mediated transcription. At 40 mg/kg, MI-136 has been shown to block AR signaling, inhibiting the growth of castration-resistant tumors in mice.
MI-136Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
MedChemexpress LLC
- Tel
- 021-58955995
- sales@medchemexpress.cn
Zhengzhou HSH Science & Technology Co., Ltd.
- Tel
- 0371-55932928 18937192232
- 1282296214@qq.com
HangZhou YuHao Chemical Technology Co., Ltd.
- Tel
- 0571-82693216
- info@yuhaochemical.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266