Decapeptide-12 Chemical Properties

Density 

1.51±0.1 g/cm3(Predicted)

pka

3.07±0.10(Predicted)

Sequence

H-Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr-OH

Cosmetics Ingredients Functions

SKIN CONDITIONING
BLEACHING

InChIKey

OYVFAMLECFSFEI-XJHNTGDTSA-N

Decapeptide-12 Usage And Synthesis

Description

Decapeptide-12 is an oligopeptide that is made up of just 10 amino acids. This oligopeptide is known for its anti-tyrosinase activity. Tyrosinase is accountable for producing melanin in the skin. Decapeptide 12 connects to tyrosinase and prevents it from catalyzing the oxidation of phenols – the initial step in melanin creation. It’s able to interfere with tyrosinase and lighten skin.

Uses

Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (Kd: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC50: 40 μM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation [1][2][3].

References

[1] Anan Abu Ubeid, et al. Short-sequence oligopeptides with inhibitory activity against mushroom and human tyrosinase. J Invest Dermatol. 2009 Sep;129(9):2242-9. DOI:10.1038/jid.2009.124
[2] Akihito Ochiai, et al. New tyrosinase inhibitory decapeptide: Molecular insights into the role of tyrosine residues. J Biosci Bioeng. 2016 Jun;121(6):607-613. DOI:10.1016/j.jbiosc.2015.10.010
[3] Basil M H, et al. Tyrosinase inhibitors with potent anti-senescence activity in human neonatal keratinocyte progenitors. J Dermatol Surg Res Ther, 2019, 2019: 30-39.

Decapeptide-12(137665-91-9)Related Product Information

• Dipeptide diaminobutyroyl benzylamide diacetate
• (2S)-N2-(1-Oxohexadecyl)-L-lysyl-L-valyl-2,4-diaminobutanoic acid bis(trifluoroacetate)
• NONAPEPTIDE-1
• L-Cysteine, L-cysteinylglycyl-L-glutaminyl-L-arginyl-L-α-glutamyl-L-threonyl-L-prolyl-L-α-glutamylglycyl-L-alanyl-L-α-glutamyl-L-alanyl-L-lysyl-L-prolyl-L-tryptophyl-L-tyrosyl-, cyclic (1→17)-disulfide
• OLIGOPEPTIDE-50
• N2-(1-Oxohexadecyl)-L-lysyl-L-valyl-(2S)-2,4-diaminobutanoyl-L-threonine bis(trifluoroacetate) (salt)
• histidyl-arginyl-alanyl-tryptophyl-phenylalanyl-lysinamide
• PALMITOYL TETRAPEPTIDE-3
• Palmitoyl Hexapeptide-12
• Tripeptide-1
• N2-(1-Oxotetradecyl)-L-lysyl-L-alanyl-L-lysyl-L-alaninamide
• H-Ala-His-Lys-OH
• decapeptide-10
• Decapeptide-18
• Decapeptide-28
• Decapeptide-23
• Oligopeptide-10
• OLIGOPEPTIDE-1