Sacubitril Impurity 7 Chemical Properties

Boiling point:

705.4±60.0 °C(Predicted)

Density 

1?+-.0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMF:30.0(Max Conc. mg/mL);78.24(Max Conc. mM)
DMSO:77.0(Max Conc. mg/mL);200.81(Max Conc. mM)
Ethanol:77.0(Max Conc. mg/mL);200.81(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.3(Max Conc. mM)

form 

A crystalline solid

pka

4.59±0.23(Predicted)

color 

White to off-white

Sacubitril Impurity 7 Usage And Synthesis

Uses

Desethyl Sacubitril is an impurity in the synthesis of Sacubitril (S080895), an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.

Sacubitril Impurity 7(149709-44-4)Related Product Information

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