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3-Hydroxy Agomelatine

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3-Hydroxy Agomelatine Basic information

Product Name:
3-Hydroxy Agomelatine
Synonyms:
  • Agomelatine 3-Hydroxy Impurity
  • Agomelatine impurity 1/3-Hydroxy Agomelatine/N-[2-(3-Hydroxy-7-methoxy-1-naphthalenyl)ethyl]acetamide
  • N-[2-(7-methoxy-3-hydroxynaphth-1-yl)ethyl]-acetamide
  • N-(2-(3-Hydroxy-7-methoxynaphthalen-1-yl)ethyl)acetamide
  • Acetamide, N-[2-(3-hydroxy-7-methoxy-1-naphthalenyl)ethyl]-
  • Agomelatine Impurity 37
  • 3-Hydroxyagomelatine
  • D3-3-Hydroxy Agomelatine
CAS:
166526-99-4
MF:
C15H17NO3
MW:
259.3
Mol File:
166526-99-4.mol
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3-Hydroxy Agomelatine Chemical Properties

Boiling point:
545.8±40.0 °C(Predicted)
Density 
1.190±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
pka
9.85±0.40(Predicted)
form 
Solid
color 
Off-white to light brown
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3-Hydroxy Agomelatine Usage And Synthesis

Uses

3-Hydroxyagomelatine-d3 is an isotope labelled compound of 3-Hydroxyagomelatine, which is an intermediate in the synthesis of 1-(aminoethyl)naphthalene derivative with potential binding affinity for melatonin receptors.

in vivo

Increasing doses (from 1.25 to 40 mg/kg, intraperitoneal injection) of 3-Hydroxy agomelatine (S 21540) does not affect the penile erections induced by mCPP and Ro 60-0175 in Wistar rat[1].

IC 50

5-HT2C Receptor: 3.2 μM (IC50); 5-HT2C Receptor: 1.8 μM (Ki)

3-Hydroxy AgomelatineSupplier

Daicel Chiral Technologies (China)CO.,LTD
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