Glycogen Phosphorylase Inhibitor Chemical Properties

Density 

1.490±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF:5.0(Max Conc. mg/mL);12.11(Max Conc. mM)
DMSO:5.0(Max Conc. mg/mL);12.11(Max Conc. mM)

form 

White powder solid.

pka

8.47±0.46(Predicted)

Glycogen Phosphorylase Inhibitor Usage And Synthesis

Description

Glycogen phosphorylase in the liver, muscle, and brain initiate glycogenolysis by releasing glucose-1-phosphate from glycogen. Glycogen phosphorylase inhibitor is a cell-permeable acyl urea first identified as an inhibitor of human liver glycogen phosphorylase (IC₅₀ = 53 nM). It blocks glucagon-induced hepatic glycogenolysis in vivo. Glycogen phosphorylase inhibitor has been used to study glycogen utilization in human liver HepG2 cells, retinal explants, and human T lymphocyte Kit 225 cells.

Uses

Glycogen Phosphorylase Inhibitor is used in biological studies to evaluate glycogen utilization in human liver HepG2 cells.

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