Basic information Safety Supplier Related

Glycogen Phosphorylase Inhibitor

Basic information Safety Supplier Related

Glycogen Phosphorylase Inhibitor Basic information

Product Name:
Glycogen Phosphorylase Inhibitor
Synonyms:
  • Glycogen Phosphorylase Inhibitor
  • 2-chloro-4,5-difluoro-N-[[2-methoxy-5-(methylcarbamoylamino)phenyl]carbamoyl]benzamide
  • Benzamide, 2-chloro-4,5-difluoro-N-[[[2-methoxy-5-[[(methylamino)carbonyl]amino]phenyl]amino]carbonyl]-
  • Glycogen Phosphorylase Inhibitor inhibitor
  • Glycogen phosphorylase-IN-1
CAS:
648926-15-2
MF:
C17H15ClF2N4O4
MW:
412.78
Mol File:
648926-15-2.mol
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Glycogen Phosphorylase Inhibitor Chemical Properties

Density 
1.490±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF:5.0(Max Conc. mg/mL);12.11(Max Conc. mM)
DMSO:5.0(Max Conc. mg/mL);12.11(Max Conc. mM)
form 
White powder solid.
pka
8.47±0.46(Predicted)
color 
white
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Glycogen Phosphorylase Inhibitor Usage And Synthesis

Description

Glycogen phosphorylase in the liver, muscle, and brain initiate glycogenolysis by releasing glucose-1-phosphate from glycogen. Glycogen phosphorylase inhibitor is a cell-permeable acyl urea first identified as an inhibitor of human liver glycogen phosphorylase (IC50 = 53 nM). It blocks glucagon-induced hepatic glycogenolysis in vivo. Glycogen phosphorylase inhibitor has been used to study glycogen utilization in human liver HepG2 cells, retinal explants, and human T lymphocyte Kit 225 cells.

Uses

Glycogen Phosphorylase Inhibitor is used in biological studies to evaluate glycogen utilization in human liver HepG2 cells.

in vivo

Glycogen phosphorylase-IN-1 (5 mg/kg, i.v., single dose) inhibits the glycogenolysis in hepatocytes, ameliorates the glucagon stimulated hyperglycemic in wistar rats[1].

Animal Model:Glucagon-stimulated hyperglycemic in wistar rats[1]
Dosage:5 mg/kg
Administration:i.v., single dose
Result:Reduced blood glucose.

References

[1] THOMAS KLABUNDE. Acyl Ureas as Human Liver Glycogen Phosphorylase Inhibitors for the Treatment of Type 2 Diabetes[J]. Journal of Medicinal Chemistry, 2005, 48 20: 6178-6193. DOI: 10.1021/jm049034y
[2] ALAN CHENG. A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori’s disease.[J]. Genes & development, 2007, 21 19: 2399-2409. DOI: 10.1101/gad.1553207
[3] KONSTANTINOS PAPPELIS. The retinal ganglion cells in metabolic syndrome.[J]. Annals of translational medicine, 2024, 12 1: 2. DOI: 10.21037/atm-23-1796
[4] ONETSINE ARRIZABALAGA. Rac1 protein regulates glycogen phosphorylase activation and controls interleukin (IL)-2-dependent T cell proliferation.[J]. The Journal of Biological Chemistry, 2012: 11878-11890. DOI: 10.1074/jbc.m111.297804

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BOC Sciences
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