Basic information Safety Supplier Related

(1S,2R,3R)-Aprepitant

Basic information Safety Supplier Related

(1S,2R,3R)-Aprepitant Basic information

Product Name:
(1S,2R,3R)-Aprepitant
Synonyms:
  • Aprepitant Impurity 7
  • 5-[[(2R,3R)-2-[(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one
  • Aprepitant (S,R,R)-Isomer
  • (2R,3R,1’S)-Aprepitant
  • Aprepitant iMpurity 31
  • Aprepitant Impurity 4(S,R,R-Isomer)
  • Aprepitant impurity 8/(1S,2R,3R)-Aprepitant
  • 5-([(2R,3R)-2-((S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy)-3-(4-fluoro phenyl)morpholino]methyl)-1H-1,2,4-triazol-3(2H)-one
CAS:
1242175-34-3
MF:
C23H21F7N4O3
MW:
534.43
Mol File:
1242175-34-3.mol
More
Less

(1S,2R,3R)-Aprepitant Chemical Properties

Density 
1.51±0.1 g/cm3(Predicted)
pka
8.06±0.20(Predicted)
More
Less

(1S,2R,3R)-Aprepitant Usage And Synthesis

Uses

(2R,3R,1’S)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.

(1S,2R,3R)-AprepitantSupplier

Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Email
chenyj@titansci.com
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Email
sales@chem-strong.com
Nanjing XiZe Biotechnology CO., Ltd.
Tel
025-66023220 0086-15250997978
Email
1511893459@qq.com
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Hubei Yangxin Medical Technology Co., Ltd.
Tel
15374522761
Email
3003392093@qq.com