(1S,2R,3R)-Aprepitant
(1S,2R,3R)-Aprepitant Basic information
- Product Name:
- (1S,2R,3R)-Aprepitant
- Synonyms:
-
- Aprepitant Impurity 7
- 5-[[(2R,3R)-2-[(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one
- Aprepitant (S,R,R)-Isomer
- (2R,3R,1’S)-Aprepitant
- Aprepitant iMpurity 31
- Aprepitant Impurity 4(S,R,R-Isomer)
- Aprepitant impurity 8/(1S,2R,3R)-Aprepitant
- 5-([(2R,3R)-2-((S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy)-3-(4-fluoro phenyl)morpholino]methyl)-1H-1,2,4-triazol-3(2H)-one
- CAS:
- 1242175-34-3
- MF:
- C23H21F7N4O3
- MW:
- 534.43
- Mol File:
- 1242175-34-3.mol
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(1S,2R,3R)-Aprepitant Chemical Properties
- Density
- 1.51±0.1 g/cm3(Predicted)
- pka
- 8.06±0.20(Predicted)
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(1S,2R,3R)-Aprepitant Usage And Synthesis
Uses
(2R,3R,1’S)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.
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(1S,2R,3R)-Aprepitant(1242175-34-3)Related Product Information
- (S)-2-((R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-4-benzylMorpholin-3-one
- (2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE
- Aprepitant
- Fosaprepitant dimeglumine
- (R,R,R)-Aprepitant
- 5-(hydroxymethyl)-1,2-dihydro-1,2,4-triazol-3-one
- Fosaprepitant Impurity 6
- 1,1,1-Trimethoxy-2-chloroethane
- Fosaprepitant Impurity 5
- Fosaprepitant
- (2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine
- Aprepitant Impurity 9
- Aprepitant
- Defluoro Aprepitant
- Aprepitant Impurity B HCl
- 5-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one
- Aprepitant Impurity 11 HCl
- Aprepitant Impurity 2