3,4-Dibromo-Mal-PEG4-t-butyl ester
3,4-Dibromo-Mal-PEG4-t-butyl ester Basic information
- Product Name:
- 3,4-Dibromo-Mal-PEG4-t-butyl ester
- Synonyms:
-
- 3,4-Dibromo-Mal-PEG4-t-butyl ester
- 3,4-Dibromo-Mal-PEG4-Boc
- tert-butyl 3-[2-[2-[2-[2-(3,4-dibromo-2,5-dioxo-pyrrol-1-yl)ethoxy]ethoxy]ethoxy]ethoxy]propanoate
- 4,7,10,13-Tetraoxapentadecanoic acid, 15-(3,4-dibromo-2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-, 1,1-dimethylethyl ester
- CAS:
- 2030168-38-6
- MF:
- C19H29Br2NO8
- MW:
- 559.24
- Mol File:
- 2030168-38-6.mol
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3,4-Dibromo-Mal-PEG4-t-butyl ester Chemical Properties
- Boiling point:
- 557.0±50.0 °C(Predicted)
- Density
- 1.503±0.06 g/cm3(Predicted)
- solubility
- Soluble in DMSO, DMF, DCM
- pka
- -6.39±0.60(Predicted)
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3,4-Dibromo-Mal-PEG4-t-butyl ester Usage And Synthesis
Description
3,4-Dibromo-Mal-PEG4-t-butyl ester is a PEG linker with a dibromomaleimide group and t-butyl protecting group. The dibromomaleimide group allows for two points of attachment because both bromine atoms can be substituted. The t-butyl ester can be removed under acidic conditions. The hydrophilic PEG chain increases the water solubility of the compound in aqueous media.
Uses
3,4-Dibromo-Mal-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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