Aminooxy-PEG3-methane Chemical Properties

storage temp. 

2-8°C, protect from light

form 

Liquid

color 

Colorless to light yellow

InChI

InChI=1S/C7H17NO4/c1-9-2-3-10-4-5-11-6-7-12-8/h2-8H2,1H3

InChIKey

UPZRLQLRXOQKOM-UHFFFAOYSA-N

SMILES

NOCCOCCOCCOC

Aminooxy-PEG3-methane Usage And Synthesis

Description

Aminooxy-PEG3-methane is a aminooxy-containing PEG reagent The hydrophilic PEG spacer increases solubility in aqueous media. The aminooxy group is reactive with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.

Uses

m-PEG3-Aminooxy is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] Luo W, et al. Tailored electroactive and quantitative ligand density microarrays applied to stem cell differentiation. J Am Chem Soc. 2010 Mar 3;132(8):2614-21. DOI:10.1021/ja907187f

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