Azido-PEG1-CH2CO2tBu Chemical Properties

storage temp. 

Store at Room Tem.

solubility 

Soluble in DCM, DMF

Azido-PEG1-CH2CO2tBu Usage And Synthesis

Description

Azido-PEG1-CH2CO2-t-Bu is a azide (N3) containing PEG linker.The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

Azido-PEG1-C1-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG1-C1-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Azido-PEG1-CH2CO2tBu(1820717-35-8)Related Product Information

• Tetrabutyl titanate
• Methyl acetate
• Azido-PEG4-t-butyl acetate
• Bromo-PEG2-CH2CO2tBu
• PEG6-(CH2CO2H)2
• Hydroxy-PEG6-CH2CO2tBu
• Bromo-PEG1-CH2CO2tBu
• Hydroxy-PEG5-t-butyl acetate