N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5 Chemical Properties

solubility 

Soluble in DMSO, DMF, DCM

N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5 Usage And Synthesis

Description

N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5 is a Cy5 labeled fluorescent PEG linker containinig DBCO group, which reacts with azide-bearing compounds or biomolecules to form a stable triazole linkage without copper catalyst. DBCO-activated fluorescein dye will be an ideal alternative to copper intolerant applications. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005