SPDP-PEG4-NHS ester Chemical Properties

Density 

1.34±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Soluble in DMSO, DCM, DMF

form 

solid or viscous liquid

pka

15.01±0.46(Predicted)

color 

White or Colorless to Almost white or Almost colorless

Water Solubility 

water: soluble

Safety Information

HS Code 

2933.39.9200

SPDP-PEG4-NHS ester Usage And Synthesis

Description

SPDP-PEG4-NHS ester is a PEG linker containing an SPDP crosslinker and an NHS ester. The SPDP crosslinker is reactive toward amine and thiol groups and contains a cleavable disulfide bond. This crosslinker is also membrane permeable which allows for intracellular reactions to take place. The NHS ester can react with primary amines to form stable amide bonds. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.

Uses

SPDP-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

reaction suitability

reagent type: cross-linking reagent

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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