Basic information Safety Supplier Related

AZD5153

Basic information Safety Supplier Related

AZD5153 Basic information

Product Name:
AZD5153
Synonyms:
  • AZD5153
  • AZD5153 (6-Hydroxy-2-naphthoic acid)
  • AZD5153 (API form)
  • 1869912-39-9 FREE BASE
  • AZD5153 (API form)(1869912-39-9 free base)
  • AZD515
  • AZD 5153 6-HYDROXY-2-NAPHTHOIC ACID; AZD-5153 6-HYDROXY-2-NAPHTHOIC ACID
  • AZD-5153 HNT salt
CAS:
1869912-40-2
MF:
C36H41N7O6
MW:
667.77
Mol File:
1869912-40-2.mol
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AZD5153 Chemical Properties

storage temp. 
Store at -20°C
solubility 
DMSO:67.0(Max Conc. mg/mL);200.67(Max Conc. mM)
Ethanol:27.0(Max Conc. mg/mL);40.43(Max Conc. mM)
form 
Solid
color 
White to off-white
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AZD5153 Usage And Synthesis

Uses

AZD5153 (6-?Hydroxy-?2-?naphthoic Acid) is a potent triazolopyridazine-based Bromodomain (BRD4) and Extraterminal (BET) inhibitor used in cancer treatments.

in vivo

Administration of AZD5153 leads to tumor stasis or regression in multiple xenograft models of acute myeloid leukemia, multiple myeloma, and diffuse large B-cell lymphoma. AZD5153 treatment markedly impacts transcriptional programs of MYC, E2F, and mTOR[1].

AZD5153Supplier

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