2-Thiazolesulfonyl chloride Chemical Properties

Boiling point:

328.5±25.0 °C(Predicted)

Density 

1.687±0.06 g/cm3(Predicted)

storage temp. 

-86°C Freezer, Under Inert Atmosphere

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly)

form 

Oil

pka

-3.33±0.10(Predicted)

color 

Clear Pale Yellow to Yellow

2-Thiazolesulfonyl chloride Usage And Synthesis

Chemical Properties

Yellow Oil

Uses

2-Thiazolesulfonyl chloride is used for preparation of substituted thiazolesulfonamides as antiglaucoma agents.

Synthesis

To a suspension of 2-mercaptothiazole (0.16 g, 1.37 mmol) in CH2Cl2 (14 mL) was added water (7 mL) followed by N-chlorosuccinimide (0.75 g, 5.6 mmol). The reaction mixture was stirred vigorously for 1.5 h. The reaction mixture was diluted with CH2Cl2, washed with saturated aqueous NaHCO3, dried and concentrated in vacuo to give 2-thiazolesulfonyl chloride in a yield of 0.25g.

2-Thiazolesulfonyl chloride(100481-09-2)Related Product Information

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• Sodium chloride
• Benzenesulfonyl chloride
• Thionyl chloride
• Sulfuryl chloride
• Ammonium chloride
• Tosyl chloride
• Calcium chloride
• Choline chloride
• Polyvinyl chloride
• Methylene Chloride
• Methanesulfonyl chloride
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