ChemicalBook > Product Catalog > Pharmaceutical intermediates > Heterocyclic compound > Pyrimidines > Esters > 2-FLUORO-4-(TRIFLUOROMETHYL)PHENYLBORONIC ACID
2-FLUORO-4-(TRIFLUOROMETHYL)PHENYLBORONIC ACID
2-FLUORO-4-(TRIFLUOROMETHYL)PHENYLBORONIC ACID Basic information
- Product Name:
- 2-FLUORO-4-(TRIFLUOROMETHYL)PHENYLBORONIC ACID
- Synonyms:
-
- 4-Borono-3-fluorobenzotrifluoride
- 2-Fluoro-4-(trifluoroMethyl)phenylboronic Acid (contains varying aMounts of Anhydride)
- 4-trifluoroMethyl-2-fluorophenylboronic acid
- 2-Fluoro-4-(trifluoroMethyl)phenylboronic Acid
- 2-Fluoro-4-(trifluoroMethyl)boronic acid
- BORONICACID, B-[2-FLUORO-4-(TRIFLUOROMETHYL)PHENYL]-
- Fluoro-4-(trifluoroMethyl)phenylboroni
- 2-FLUORO-4-(TRIFLUOROMETHYL)BENZENEBORONIC ACID
- CAS:
- 503309-11-3
- MF:
- C7H5BF4O2
- MW:
- 207.92
- EINECS:
- 225-734-0
- Product Categories:
-
- Boronic Acid
- blocks
- BoronicAcids
- Aryl
- Organoborons
- Mol File:
- 503309-11-3.mol
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2-FLUORO-4-(TRIFLUOROMETHYL)PHENYLBORONIC ACID Chemical Properties
- Melting point:
- 113-115°C
- Boiling point:
- 251.9±50.0 °C(Predicted)
- Density
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- powder to crystal
- pka
- 7.62±0.58(Predicted)
- color
- White to Light yellow
- InChI
- InChI=1S/C7H5BF4O2/c9-6-3-4(7(10,11)12)1-2-5(6)8(13)14/h1-3,13-14H
- InChIKey
- SSFSVKVWAURAAM-UHFFFAOYSA-N
- SMILES
- B(C1=CC=C(C(F)(F)F)C=C1F)(O)O
- CAS DataBase Reference
- 503309-11-3(CAS DataBase Reference)
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Safety Information
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22-36
- Safety Statements
- 26-36/37/39-36-37
- WGK Germany
- WGK 3
- HazardClass
- IRRITANT
- HS Code
- 29319090
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2
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2-FLUORO-4-(TRIFLUOROMETHYL)PHENYLBORONIC ACID Usage And Synthesis
Chemical Properties
White crystalline powder
Uses
2-Fluoro-4-trifluoromethylphenylboronic acid
Synthesis
To a stirred solution of 5-bromo-2-(methylthio)pyrimidine (950 mg, 4.63 mmol) in DMF (5 mL) was added 4,4,4??,4??,5,5,5??,5??-octamethyl-2,2??-bis(1,3,2-dioxaborolane) (1.77 g, 6.95 mmol), potassium acetate (1.36 g , 13.90 mmol) and palladium diacetate (104 mg, 0.463 mol). The resulting suspension was degassed with argon for 15 minutes and then heated at 85??C overnight. The reaction mixture was allowed to cool to room temperature. EtOAc (10 mL) was added to the reaction mixture and the reaction mixture was washed with brine (15 mLx3). The organic phase was dried (MgSO4), filtered and concentrated to give 2-methylthiopyrimidine-5-boronic acid pinacol ester.
2-FLUORO-4-(TRIFLUOROMETHYL)PHENYLBORONIC ACIDSupplier
Hebei Maison Chemical Co.,Ltd. Gold
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- 155-11852758 15511852758
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GUANGZHOU AANPHARM TECHNOLOGY CO.,LTD Gold
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- 020-86211473 13925088720
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J & K SCIENTIFIC LTD.
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- 18210857532; 18210857532
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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- 4006356688 18621169109
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Alfa Aesar
- Tel
- 400-6106006
- saleschina@alfa-asia.com
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2-FLUORO-4-(TRIFLUOROMETHYL)PHENYLBORONIC ACID(503309-11-3)Related Product Information
- 2-FLUORO-4-(TRIFLUOROMETHYL)PHENYLBORONIC ACID
- 2-FLUORO-5-(TRIFLUOROMETHYL)PHENYLBORONIC ACID
- 4-Fluoro-2-trifluoromethyl-phenylboronic acid
- 3-FLUORO-4-TRIFLUOROMETHYL-PHENYLBORONIC ACID
- 3-Fluoro-4-(trifluoromethyl)phenylboronic acid pinacol ester
- 2-FLUORO-3-(TRIFLUOROMETHYL)PHENYLBORONIC ACID
- 4-FLUORO-3-(TRIFLUOROMETHYL)PHENYLBORONIC ACID
- 4-Fluoro-3-(trifluoromethyl)phenylboronic acid pinacol ester
- 5-FLUORO-2-(TRIFLUOROMETHYL)PHENYLBORONIC ACID
- 2-Fluoro-4-methylphenylboronic acid
- 4-Difluoromethyl-phenylboronic acid
- 2-FLUORO-4-TRIFLUOROMETHYLPHENYLBORONIC ACID, PINACOL ESTER
- 4-Trifluoromethylphenylboronic acid