QUININE SULFATE
QUININE SULFATE Basic information
- Product Name:
- QUININE SULFATE
- Synonyms:
-
- Quinine sulfate(2:1)
- 6’-methoxy-cinchonan-9-o(8alpha,9theta)-cinchonan-9-osulfate(2:1)(salt)
- Cinchonan-9-ol,6’-methoxy-,(8.alpha.,9R)-,sulfate(2:1)(salt)
- legatrin
- quininehydrogensulfate
- QUININE HEMISULFATE
- QUININE BISULFATE
- QUININE SULFATE
- CAS:
- 804-63-7
- MF:
- C40H50N4O8S
- MW:
- 746.91
- EINECS:
- 212-359-2
- Product Categories:
-
- Organics
- Mol File:
- 804-63-7.mol
QUININE SULFATE Chemical Properties
- Melting point:
- 235.2°C
- Density
- 1.0807 (rough estimate)
- refractive index
- 1.6000 (estimate)
- Odor
- wh. fine needle-like cryst., odorless, very bitter taste
- BCS Class
- 1
- LogP
- 3.44
- CAS DataBase Reference
- 804-63-7(CAS DataBase Reference)
- EPA Substance Registry System
- Quinine sulfate (2:1) (804-63-7)
QUININE SULFATE Usage And Synthesis
Chemical Properties
White powder
Uses
ntimalarial.
Uses
Quinine, an extremely bitter substance, has been used by millions of malaria sufferers. In recent times, it has been employed successfully to treat chloroquine-resistant strains of P. falciparum but it frequently fails to provide a complete cure of the infection.
Definition
ChEBI: A organic sulfate salt obtained from guanethidine and sulfuric acid in a 2:1 ratio.
brand name
Coco-Quinine (Lilly).
World Health Organization (WHO)
Quinine is an important drug in the treatment of multi- drugresistant forms of malaria. Its use in nocturnal leg muscle cramps, a benign and self-limiting condition, is connected with unjustified risks. Quinine is listed in the WHO Model List of Essential Drugs for treatment of malaria.
Safety Profile
Human poison by ingestion. Human systemic effects by ingestion: acuity changes, blood agranulocytosis, fibrous hepatitis, flaccid paralysis without anesthesia, motor activity changes, mydriasis (pupillary dilation), nausea or vomiting, tinnitus, visual field changes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of SO, and NO,. See also QUININE.
Purification Methods
Crystallise it from water and dry it at 110o. [Beilstein 23 H 522, 23 I 168, 23 II 420, 23 III/IV 3269, 23 V 396.]
QUININE SULFATE Preparation Products And Raw materials
Preparation Products
Raw materials
QUININE SULFATESupplier
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QUININE SULFATE(804-63-7)Related Product Information
- Quinine
- Quinine sulfate dihydrate
- QUINUCLIDINE
- Quinine sulfate dihudrate
- QUININE SULFATE
- quinine,sulfate(1:1)(salt),heptahydrat
- QUININE SULFATE SALT MONOHYDRATE
- Quinine sulfate *Fluorescence Reference Standard
- QUININE SULFATE, FLUORESCENCE
- QUININE SULFATE USP(CRM STANDARD)
- QUININE SULFATE SALT
- QUININE SULFATE
- Quinine Sulphate