GTP-GAMMA-S TETRALITHIUM SALT Chemical Properties

storage temp. 

-20°C

solubility 

H₂O: ≥75 mg/mL Solutions are very unstable; prepare immediately prior to use.

form 

powder

color 

off-white

Water Solubility 

Water: 75 mg/ml

BRN 

8182249

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

F 

10-21

MSDS

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GTP-GAMMA-S TETRALITHIUM SALT Usage And Synthesis

Uses

Guanosine 5′-[γ-thio]triphosphate tetralithium salt has been used:

• as a component of lysis buffer
• in oocyte and mammalian cell patch-clamp experiments to keep the G proteins in a constantly active state
• to couple with G- protein α, to study its effect on kinase activity

General Description

G-protein-activating GTP analog, which is more resistant to hydrolysis than GTP. Induces exocytosis in isolated mouse pancreatic acinar cells. Also reported to stimulate insulin release from pancreatic β-cells.

Biochem/physiol Actions

GTP-γ-S is a non-hydrolyzable GTP analog, known for its role as a G-protein activator. It has recently been shown to protect proteins from proteolytic degradation, stimulate GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization in vitro.

GTP-GAMMA-S TETRALITHIUM SALT(94825-44-2)Related Product Information

• GTP
• GTP-GAMMA-S TETRALITHIUM SALT
• PHOSPHOROTHIOATE
• GDP