H2N-PEG11-OH Chemical Properties

Boiling point:

565.6±45.0 °C(Predicted)

Density 

1.098±0.06 g/cm3(Predicted)

storage temp. 

Store at Room Tem.

solubility 

Soluble in Water, DMSO, DMF, DCM

pka

14.36±0.10(Predicted)

H2N-PEG11-OH Usage And Synthesis

Description

Amino-PEG11-alcohol is a crosslinking reagent consisting of an amino (NH2) group with a hydroxyl(OH) group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydroxyl (OH) enables further derivatization.

Uses

Amino-PEG11-OH is non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG11-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

Non-cleavable Linker; PEGs

References

[1] Synthesis of reduced sensitive azo connection unit and application of azo connection unit in DNA (deoxyribonucleic acid) sequencing. CN103539697A.

H2N-PEG11-OH(15332-94-2)Related Product Information

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