BocNH-PEG7-CH2CH2N3 Usage And Synthesis

Description

t-boc-N-amido-PEG7-azide is a PEG molecule with an azide(N3) group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group is reactive with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Uses

Boc-NH-PEG7-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-NH-PEG7-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

BocNH-PEG7-CH2CH2N3(206265-96-5)Related Product Information

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• Azide-PEG7-Tos
• Amino-PEG8-azide
• Azido-PEG8-acid
• Azido-PEG7-hydrazide
• Azido-PEG7-azide
• Azido-PEG7-COOtBu
• N3-PEG7-OH
• t-Boc-N-Amido-PEG2-Azide
• Azido-PEG4-NHBoc