Fmoc-NH-PEG6-CH2COOH Chemical Properties

storage temp. 

2-8°C

form 

Viscous Liquid

color 

Colorless to light yellow

Fmoc-NH-PEG6-CH2COOH Usage And Synthesis

Description

Fmoc-NH-PEG6-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

Fmoc-NH-PEG6-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG6-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

Cleavable Linker; Alkyl/ether; PEGs

References

[1] Michael A, et al. Synthesis of Bifunctional Integrin‐Binding Peptides Containing PEG Spacers of Defined Length for Non‐Viral Gene Delivery. Volume2008, Issue17.

Fmoc-NH-PEG6-CH2COOH(437655-96-4)Related Product Information

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