M-3M3FBS Chemical Properties

Melting point:

114-114.8 °C(lit.)

Boiling point:

420.0±55.0 °C(Predicted)

Density 

1.316±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO: 92 mg/mL

form 

solid

pka

7.82±0.10(Predicted)

color 

white

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

M-3M3FBS Usage And Synthesis

Description

m-3M3FBS (200933-14-8) is an activator of phospholipase C (PLC). Stimulates superoxide generation, Ca2+ release and inositol phosphate release in a variety of cell types.1?Inhibits growth of U937 and THP-1 cells.2 m-3M3FBS also affects calcium homeostasis independently of PLC activation.3

Uses

m-3M3FBS is used in biological studies as phospholipase C activator m-3M3FBS effects on Ca2+ homeostasis independently of phospholipase C activation.

Uses

m-3M3FBS has been used for MAP kinase assay in 293T cells. It has also been used for intracellular calcium analysis¹. Furthermore, it has been used (at a conc. of 1 μM) as a PLC activator for sensitizing TRPA1 in HEK293t cells².

Definition

ChEBI: 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide is a sulfonamide.

Biological Activity

Activator of phospholipase C (PLC). Stimulates superoxide generation, Ca 2+ release and inositol phosphate formation in a variety of cell types.

Biochem/physiol Actions

First known direct activator of phospholipase C (activates β2, β3, γ1, γ2, δ1 isoforms).

storage

Store at RT

References

1) Bae?et al. (2003),?Identification of a compound that directly stimulates phospholipase C activity; Mol. Pharmacol.,?63?1043 2) Lee?et al. (2005),?The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis; Cancer Lett.,?222?227 3) Krjukova?et al. (2004),?Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation; Br. J. Pharmacol.,?143?3

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