Biotin-PEG3-CH2COOH CAS#: 1189560-96-0

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Biotin-PEG3-CH2COOH

Basic information Safety Supplier Related

Biotin-PEG3-CH2COOH Basic information

Product Name:

Biotin-PEG3-CH2COOH

Synonyms:

Biotin-PEG3-acetic Acid
13-oxo-17-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-3,6,9-trioxa-12-azaheptadecanoic acid
Biotin-PEG3-CH2COOH
CAS_1189560-96-0
3,6,9-Trioxa-12-azaheptadecanoic acid, 17-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-13-oxo-
11-(Biotinamido)-3,6,9-trioxaundecanoic Acid
13-oxo-17-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-3,6,9-trioxa-12-azaheptadecan-1-oic acid
Biotin-PEG3-CH2COOH/3,6,9-Trioxa-12-azaheptadecanoic acid, 17-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-13-oxo-

CAS:

1189560-96-0

MF:

C18H31N3O7S

MW:

433.52

Product Categories:

Mol File:

1189560-96-0.mol

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Biotin-PEG3-CH2COOH Usage And Synthesis

Biological Activity

Biotin-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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