RET Kinase inhibitor 1 Chemical Properties

Boiling point:

670.1±55.0 °C(Predicted)

Density 

1.37±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO:81.0(Max Conc. mg/mL);173.29(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.53(Max Conc. mM)
Ethanol:15.5(Max Conc. mg/mL);33.16(Max Conc. mM)

form 

A crystalline solid

pka

10.30±0.10(Predicted)

color 

White to off-white

RET Kinase inhibitor 1 Usage And Synthesis

Description

GSK3179106 is an inhibitor of rearranged during transfection (RET) kinase (IC₅₀ = 0.4 nM). It is selective for RET kinase over VEGF receptor 2 (VEGFR2/KDR; IC₅₀ = 109 nM). GSK3179106 reduces the number of abdominal contractions induced by colorectal distension in acetic acid-sensitized rats when administered at a dose of 10 mg/kg twice per day.

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