RET Kinase inhibitor 1 Chemical Properties

Boiling point:

670.1±55.0 °C(Predicted)

Density 

1.37±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO:81.0(Max Conc. mg/mL);173.29(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.53(Max Conc. mM)
Ethanol:15.5(Max Conc. mg/mL);33.16(Max Conc. mM)

form 

A crystalline solid

pka

10.30±0.10(Predicted)

RET Kinase inhibitor 1 Usage And Synthesis

Description

GSK3179106 is an inhibitor of rearranged during transfection (RET) kinase (IC₅₀ = 0.4 nM). It is selective for RET kinase over VEGF receptor 2 (VEGFR2/KDR; IC₅₀ = 109 nM). GSK3179106 reduces the number of abdominal contractions induced by colorectal distension in acetic acid-sensitized rats when administered at a dose of 10 mg/kg twice per day.

RET Kinase inhibitor 1(1627856-64-7)Related Product Information

• N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide
• GSK484
• GSK583
• GSK369796
• GSK461364
• GSK547
• GSK-467
• GSK481
• GSK-3326595
• 4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide