Aminooxy-PEG3-NH-Boc Chemical Properties

Boiling point:

440.0±40.0 °C(Predicted)

Density 

1.083±0.06 g/cm3(Predicted)

storage temp. 

2-8°C, sealed storage, away from moisture and light

solubility 

Soluble in DMSO, DMF, Methanol

pka

12.23±0.46(Predicted)

form 

Liquid

color 

Colorless to light yellow

Aminooxy-PEG3-NH-Boc Usage And Synthesis

Description

Aminooxy-PEG3-NH-Boc is a PEG linker containing an aminooxy group and a Boc protected amine group. The hydrophilic PEG spacer increases solubility in aqueous media. The aminooxy group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The protected amine can be deprotected under acidic conditions. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.

Uses

Aminooxy-PEG3-C2-NH-Boc is a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

Aminooxy-PEG3-NH-Boc(2062663-65-2)Related Product Information

• Boc-Aminooxy-PEG3-acid
• Aminooxy-PEG7-methane
• Aminooxy-PEG3-methane
• Boc-Aminooxy-PEG2-amine
• Aminooxy-PEG4-t-butyl ester
• Aminooxy-PEG2-alcohol
• Aminooxy-PEG4-alcohol
• Aminoxy-PEG4-acid
• Aminooxy-PEG8-methane
• Aminooxy-PEG3-thiol
• Aminooxy-PEG2-methane
• Boc-Aminooxy-PEG3-amine
• Aminooxy-PEG3-t-butyl ester
• Aminoxy-PEG3-acid
• Aminooxy-PEG4-Propargyl
• Aminooxy-PEG1-NH-Boc
• Aminooxy-PEG5-Aminooxy
• Aminooxy-PEG1-acid