N-azidoacetylmannosamine-tetraacylated Chemical Properties

storage temp. 

-20°C

solubility 

DMSO:100 mg/mL (232.36 mM; Need ultrasonic

form 

powder or crystals

N-azidoacetylmannosamine-tetraacylated Usage And Synthesis

Application

N-Azidoacetylmannosamine-tetraacylated (Ac4ManNAz) is an azide-containing metabolic glycoprotein labeling reagent that can be incorporated into the sialic acid biosynthesis pathway. The azide-modified protein can be detected by reaction with alkynes. For example alkynes labeled with a fluorescent probe or a biotin can be used. The acetyl groups increase cell permeability and allow the unnatural sugars to easily pass through the cell membrane. Carboxyesterases remove the acetyl groups once the monosaccharide is in the cell.

Description

N-azidoacetylmannosamine-tetraacylated (Ac4ManNAz) is an unnatural azido-containing monosaccharide building block. The azide moiety can be used for modification though chemoselective ligation chemistries including CuAAC, Cu-free click reaction or Staudinger ligation. The acetyl groups increase solubility in many solvents and make handling of this reagent easier.

Uses

Tetraacylated N-azidoacetylmannosamine is generally used in click chemistry applications in bioconjugate chemistry.

storage

Store at -20°C

N-azidoacetylmannosamine-tetraacylated(361154-30-5)Related Product Information

• 2-[(2-Azidoacetyl)amino]-2-deoxy-D-galactose
• 2-[(2-Azidoacetyl) amino] -2-deoxy-D-glu- copyranose
• 2-[(Azidoacety)amino]-2-deoxy-D-mannose
• 2-[(Azidoacetyl)aMino]-2-deoxy-D-glucose
• N-azidoacetylgalactosamine-tetraacylated (Ac4GaINAz)