ethyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate Chemical Properties

Boiling point:

332.3±27.0 °C(Predicted)

Density 

1.105±0.06 g/cm3(Predicted)

pka

14.36±0.10(Predicted)

ethyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate Usage And Synthesis

Biological Activity

Hydroxy-PEG3-ethyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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