N-Mal-N-bis(PEG4-NHS ester)
N-Mal-N-bis(PEG4-NHS ester) Basic information
- Product Name:
- N-Mal-N-bis(PEG4-NHS ester)
- Synonyms:
-
- N-Mal-N-bis(PEG4-NHS ester)
- 4,7,10,13,19,22,25,28-Octaoxa-16-azahentriacontanedioic acid, 16-[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]-, 1,31-bis(2,5-dioxo-1-pyrrolidinyl) ester
- Bis(2,5-dioxopyrrolidin-1-yl) 16-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl)-4,7,10,13,19,22,25,28-octaoxa-16-azahentriacontane-1,31-dioate
- CAS:
- 2112738-60-8
- MF:
- C37H54N4O19
- MW:
- 858.84
- Mol File:
- 2112738-60-8.mol
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N-Mal-N-bis(PEG4-NHS ester) Chemical Properties
- Boiling point:
- 892.3±75.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- solubility
- Soluble in DMSO, DCM, DMF
- pka
- -0.93±0.70(Predicted)
- form
- Liquid
- color
- Colorless to light yellow
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N-Mal-N-bis(PEG4-NHS ester) Usage And Synthesis
Description
N-Mal-N-bis(PEG4-NHS ester) is a branched maleimide linker with two terminal NHS esters. NHS esters is used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule.
Uses
N-Mal-N-bis(PEG4-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
N-Mal-N-bis(PEG4-NHS ester)Supplier
Borenpharm Co., Ltd
- Tel
- 027-65563561
- sales@borenpharm.com
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
Zhengzhou Acme Chemical Co., Ltd.
- Tel
- 0371-0371-55629727 13323845623
- 2885676761@qq.com
Xi'an Confluore Biological Technology Co., Ltd.
- Tel
- +86-156-80926068 +86-15680926068
- 1924344760@qq.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
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N-Mal-N-bis(PEG4-NHS ester)(2112738-60-8)Related Product Information
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- N-Mal-N-bis(PEG2-NHS ester)
- N-Mal-N-bis(PEG4-NH-Boc)
- N-Mal-N-bis(PEG2-NH-Boc)
- N-Mal-N-bis(PEG2-t-butyl ester)
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- INDEX NAME NOT YET ASSIGNED
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