4-Amino-4'-chlorodiphenyl ether
4-Amino-4'-chlorodiphenyl ether Basic information
- Product Name:
- 4-Amino-4'-chlorodiphenyl ether
- Synonyms:
-
- 4-(4-chlorophenoxy)-benzenamin
- 4’-chloro-4-aminobiphenylether
- 4-chloro-4’-aminodiphenylether
- JR-8688, 4-(4-Chlorophenoxy)benzenamine, 97%
- p-(p-chlorophenoxy)-anilin
- SALOR-INT L300845-1EA
- P-(P-CHLOROPHENOXY)ANILINE
- 4-(4'-CHLOROPHENOXY)ANILINE
- CAS:
- 101-79-1
- MF:
- C12H10ClNO
- MW:
- 219.67
- EINECS:
- 202-976-5
- Product Categories:
-
- API Intermediate
- Benzene series
- Biphenyl & Diphenyl ether
- Amines
- C11 to C38
- Nitrogen Compounds
- Diphenyl Ethers (for High-Performance Polymer Research)
- Functional Materials
- Reagent for High-Performance Polymer Research
- Mol File:
- 101-79-1.mol
4-Amino-4'-chlorodiphenyl ether Chemical Properties
- Melting point:
- 99-103 °C
- Boiling point:
- 205 °C / 12mmHg
- Density
- 1.1764 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- pka
- 4.60±0.10(Predicted)
- form
- powder to crystal
- color
- White to Light yellow to Light orange
- Water Solubility
- Insoluble in water.
- CAS DataBase Reference
- 101-79-1(CAS DataBase Reference)
- EPA Substance Registry System
- Benzenamine, 4-(4-chlorophenoxy)- (101-79-1)
Safety Information
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-40-43-41-37/38-22
- Safety Statements
- 26-36/37/39-36/37
- WGK Germany
- 3
- RTECS
- BX1770000
- TSCA
- Yes
- HazardClass
- IRRITANT
- HS Code
- 29222990
MSDS
- Language:English Provider:ALFA
4-Amino-4'-chlorodiphenyl ether Usage And Synthesis
Chemical Properties
Dark powder
Uses
It is used as an active pharmaceutical intermediate.
Synthesis
1836-74-4
101-79-1
General procedure for the synthesis of 4'-chloro-4-amino-diphenyl ether from 4'-chloro-4-nitro-diphenyl ether: general method: 1-substituted-4-nitrobenzene (9.3 mmol) and hydrazine hydrate (27.9 mmol) were dissolved in 20 mL of ethanol, and stirred for 10 min at 28-30°C. The reaction was carried out in aqueous suspension of Raney-Ni (0.02 g). An aqueous suspension of Raney-Ni (0.02 g, 4.41 mL) was added in three 10-min intervals. after 30 min, the reaction was allowed to plateau, and the temperature was raised to 50-60 °C to continue stirring for 6 h. The catalyst was removed by filtration. After completion of the reaction, the catalyst was removed by filtration. The solvent was removed by evaporation to give the target product 4'-chloro-4-amino-diphenyl ether.
References
[1] Green Chemistry, 2017, vol. 19, # 14, p. 3400 - 3407
[2] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 7, p. 1588 - 1592
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 11, p. 4811 - 4815
[4] Pharmazie, 1980, vol. 35, # 2, p. 78 - 80
[5] Pharmazie, 1980, vol. 35, # 2, p. 78 - 80
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4-Amino-4'-chlorodiphenyl ether(101-79-1)Related Product Information
- 1-(4-Chlorophenoxy)-4-nitrobenzene
- 2-CHLORO-1-(2,4-DICHLOROPHENOXY)-4-NITROBENZENE
- NITROFEN
- CHLOROXURON
- 4-Cyanotetrahydropyran
- 2,4-DICHLORO-4'-AMINODIPHENYL ETHER
- 4-Amino-4'-chlorodiphenyl ether
- Bifenox
- 2-AMINO-4'-CHLORODIPHENYL ETHER
- 5-Chloro-2-phenoxyaniline
- 4-Phenoxyaniline
- Diphenyl ether
- 4-Chlorodiphenyl ether
- 2-CHLORO-N-[4-(4-CHLOROPHENOXY)PHENYL]ACETAMIDE
- 4-(3,4-DICHLOROPHENOXY)ANILINE
- 2,4'-DICHLORO-4-NITRODIPHENYL ETHER
- 2,4,5-TRICHLOROPHENYL-4-NITROPHENYL ETHER
- 4-(4-CHLORO-3-METHYLPHENOXY)ANILINE