Isobutyramide Chemical Properties

Melting point:

127-131 °C (lit.)

Boiling point:

216-220 °C (lit.)

Density 

1.013 g/mL at 25 °C (lit.)

refractive index 

1.4345 (estimate)

Flash point:

216-220°C

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Sparingly), DMSO (Slightly)

form 

Solid

pka

16.60±0.50(Predicted)

color 

White to Off-White

Water Solubility 

Soluble in water.

LogP

0.003 (est)

CAS DataBase Reference

563-83-7(CAS DataBase Reference)

NIST Chemistry Reference

Propanamide, 2-methyl-(563-83-7)

EPA Substance Registry System

Propanamide, 2-methyl- (563-83-7)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

24/25

WGK Germany 

3

RTECS 

TX1475000

TSCA 

Yes

HS Code 

29241990

MSDS

• Language:English Provider:2-Methylpropionamide
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Isobutyramide Usage And Synthesis

Chemical Properties

white needle-like crystalline powder

Uses

Isobutyramide could be a useful compound for technical applications as a component in environmentally-friendly automobile welding anti-spatter liquid.

Uses

Isobutyramide plays an important role in chemical grafting of human serum albumin during the synthesis of sequentially assembled protein capsules. It is used in pharmaceutical manufacturing and in cellular differentiation. It finds application in the transcription of human gamma-globin gene and murine embryonic epsilon(y)-globin gene. Further, it is in the treatment of beta-thalassemia and sickle cell disease.

Definition

ChEBI: Isobutyramide is a carboximidic acid.

Application

Isobutyramide was used for chemical grafting of human serum albumin during the synthesis of sequentialy assembled protein capsules.
Isobutyramide plays an important role in chemical grafting of human serum albumin during the synthesis of sequentially assembled protein capsules. It is used in pharmaceutical manufacturing and in cellular differentiation. It finds application in the transcription of human gamma-globin gene and murine embryonic epsilon(y)-globin gene. Further, it is in the treatment of beta-thalassemia and sickle cell disease.

Synthesis Reference(s)

Journal of the American Chemical Society, 69, p. 2058, 1947 DOI: 10.1021/ja01200a070

Biochem/physiol Actions

Isobutyramide activates transcription of human gamma-globin gene and murine embryonic epsilon(y)-globin gene. It is useful in the treatment of β-thalassemia and sickle cell disease.

Purification Methods

Crystallise the amide from acetone, *benzene, CHCl3, EtOAc or water, then dry it under vacuum over P2O5 or 99% at H2SO4, or at 70o/3hours in a desiccator. Sublime it under vacuum. [Kent & McAlvain Org Synth Coll Vol III 491 1955, Beilstein 2 H 293, 2 I 129, 2 II 262, 2 III 654, 2 IV 852.]

Isobutyramide(563-83-7)Related Product Information

• Boc-D-Glutamine
• Isobutyrophenone
• Nicotinamide
• Formamide
• Acrylamide
• 2-Bromoisobutyryl Bromide
• N,N-Dimethylformamide
• Polyacrylamide
• 2-Aminobutanamide
• Butyramide
• Polyamide
• Methyl isobutyrylacetate
• Isobutyric acid hydrazide
• Isobutyryl chloride
• Ethyl isobutyrylacetate
• ISOBUTYRYL BROMIDE
• N-acetyl aspartyl-glutaMic acid
• ISOBUTYRIC ACID POTASSIUM SALT