(S)-(+)-1-Aminoindan Chemical Properties

Melting point:

15 °C

alpha 

20 º (c=1.5, CH3OH)

Boiling point:

96-97 °C8 mm Hg(lit.)

Density 

1.038 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.562(lit.)

Flash point:

202 °F

storage temp. 

Keep in dark place,Sealed in dry,2-8°C

solubility 

soluble in DMSO, Methanol

form 

Liquid

pka

9.44±0.20(Predicted)

color 

Clear yellow

optical activity

[α]20/D +16.5°, c = 1.5 in methanol

Water Solubility 

insoluble

Sensitive 

Air Sensitive

BRN 

2206708

Stability:

Hygroscopic

InChI

1S/C9H11N/c10-9-6-5-7-3-1-2-4-8(7)9/h1-4,9H,5-6,10H2/t9-/m0/s1

InChIKey

XJEVHMGJSYVQBQ-VIFPVBQESA-N

SMILES

N[C@H]1CCc2ccccc12

CAS DataBase Reference

61341-86-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-52/53

Safety Statements 

26-36-37/39-61

RIDADR 

UN 3082 9 / PGIII

WGK Germany 

3

F 

10-34

HS Code 

29214990

Storage Class

10 - Combustible liquids

Hazard Classifications

Aquatic Chronic 3
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

(S)-(+)-1-Aminoindan Usage And Synthesis

Chemical Properties

clear yellow liquid

Uses

(S)-1-Aminoindane is the S-enantiomer of 1-Aminoindane; the metabolite of the monoamine oxidase-B inhibitor Rasagiline (R126000).

Synthesis

Add 1.00 g (4.80 mmol) of di-(S-(+)-1-aminoindan)- D-tartrate to a 250 mL flask, 40 mL of water, heated with stirring to dissolve completely, cooled to room temperature, added 20% NaOH solution dropwise, adjusted the PH to 10, and extracted with 40 mL each time. Trichloromethane was extracted three times, the organic phases were combined, dried with anhydrous magnesium sulfate for 20 min, filtered and concentrated to obtain 0.97 g of light yellow liquid (S)-(+) . -1-aminoindan, ee value (HPLC method) was 79.6%, the yield was 97.0%.

(S)-(+)-1-Aminoindan(61341-86-4)Related Product Information

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