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METHYL PHOSPHORODICHLORIDITE

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METHYL PHOSPHORODICHLORIDITE Basic information

Product Name:
METHYL PHOSPHORODICHLORIDITE
Synonyms:
  • METHYL DICHLOROPHOSPHITE, TECHNICAL GRADE
  • O-Methyl Phosphorodichloridite
  • Methoxydichlorophosphine
  • Methoxyphosphonous Dichloride
  • O-Methyl Phosphorodichloridit
  • Methyl Dichlorophosphite [Phosphitylating Agent]
  • Methyl dichlorophosphite,98%
  • Methyl dichlorophosphite, 98% 5ML
CAS:
3279-26-3
MF:
CH3Cl2OP
MW:
132.91
EINECS:
221-915-3
Product Categories:
  • Pyridine
  • All Aliphatics
  • Biochemistry
  • Nucleosides, Nucleotides & Related Reagents
  • Phosphorylating and Phosphorothioating Agents
  • Phosphorylation
  • Protecting Agents, Phosphorylating Agents & Condensing Agents
  • Synthetic Organic Chemistry
  • Aliphatics
  • Phosphorylating and Phosphitylating Agents
  • Building Blocks
  • Chemical Synthesis
  • Organic Building Blocks
  • Phosphorus Compounds
  • Phosphorus Halides
Mol File:
3279-26-3.mol
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METHYL PHOSPHORODICHLORIDITE Chemical Properties

Melting point:
-91 °C (lit.)
Boiling point:
93-95 °C (lit.)
Density 
1.376 g/mL at 20 °C (lit.)
refractive index 
n20/D 1.474(lit.)
Flash point:
104 °F
storage temp. 
−20°C
solubility 
soluble in Chloroform, Dichloromethane, Ethyl Acetate
form 
liquid
color 
Colorless to Almost colorless
Water Solubility 
Reacts with water. Soluble in chloroform, dichloromethane and ethyl acetate.
Sensitive 
Moisture Sensitive
BRN 
1697452
Stability:
Flammable.
CAS DataBase Reference
3279-26-3(CAS DataBase Reference)
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Safety Information

Hazard Codes 
C
Risk Statements 
10-14-34-37
Safety Statements 
26-36/37/39-45
RIDADR 
UN 2920 8/PG 2
WGK Germany 
3
10-13-23
HazardClass 
8
PackingGroup 
II
HS Code 
29209090

MSDS

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METHYL PHOSPHORODICHLORIDITE Usage And Synthesis

Chemical Properties

Colourless Liquid

Uses

Employed in the synthesis of phosphorodichloridothioates1 and oxazaphosphorinanes2 from sulfenyl chlorides and a chiral amino alcohol, respectively.

Uses

Methyl dichlorophosphite has been employed in the preparation of:

  • phosphonamidate- and phosphonate-linked phosphonopeptides
  • 2-(2-iodophenyl)ethyl methyl phosphite derivative of an alcohol
  • deoxyoligonucleotides on a polymer support
  • cis- and trans-2-oxo-2-propionyl-1,3,2-oxazaphosphorinane
  • phosphorodichloridothioates
  • oxazaphosphorinanes

METHYL PHOSPHORODICHLORIDITESupplier

J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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4006608290; 18621169109
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Alfa Aesar
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400-6106006
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TCI (Shanghai) Development Co., Ltd.
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021-67121386
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Sales-CN@TCIchemicals.com
Energy Chemical
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021-021-58432009 400-005-6266
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sales8178@energy-chemical.com